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Kunio Kosaka Selected Research

salvin

5/2015Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.
2/2014Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells.
2/2013Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
11/2012Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration.
8/2011Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.
4/2011Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.
1/2011Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice.
11/2003Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98G human glioblastoma cells.

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Kunio Kosaka Research Topics

Disease

4Alzheimer Disease (Alzheimer's Disease)
12/2016 - 02/2013
3Neuroblastoma
05/2015 - 02/2013
2Astrocytoma (Pilocytic Astrocytoma)
04/2019 - 02/2014
2Glioblastoma (Glioblastoma Multiforme)
08/2011 - 11/2003
1Retinal Degeneration
11/2012
1Reperfusion Injury
04/2011
1Hypoxia (Hypoxemia)
04/2011
1Atherosclerosis
02/2011
1Neoplasms (Cancer)
02/2011
1Obesity
01/2011
1Weight Loss (Weight Reduction)
01/2011
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
03/2010
1Ischemia
02/2008
1Melanoma (Melanoma, Malignant)
11/2007

Drug/Important Bio-Agent (IBA)

8salvinIBA
05/2015 - 11/2003
4Nerve Growth Factor (NGF)IBA
04/2019 - 11/2003
4Peptides (Polypeptides)IBA
12/2016 - 02/2013
4Amyloid (Amyloid Fibrils)IBA
12/2016 - 02/2013
3Amyloid beta-PeptidesIBA
05/2015 - 02/2013
2AntioxidantsIBA
04/2019 - 11/2012
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
02/2014 - 02/2013
1DiterpenesIBA
02/2014
1Proteins (Proteins, Gene)FDA Link
02/2013
1Metalloproteases (Metalloproteinases)IBA
02/2013
1Retinaldehyde (Retinal)IBA
11/2012
1Messenger RNA (mRNA)IBA
08/2011
1EdaravoneIBA
04/2011
1Triglycerides (Triacylglycerol)IBA
01/2011
1CholesterolIBA
01/2011
1Rosmarinic AcidIBA
03/2010
1Glutathione (Reduced Glutathione)IBA
02/2008
1Monophenol Monooxygenase (Tyrosinase)IBA
11/2007

Therapy/Procedure

1Chinese Traditional Medicine (Traditional Chinese Medicine)
02/2011